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Project TitleA Novel Proto-Oncogene for Early Stage Detection and Targeted Treatment of Multiple Cancer Types
Track CodeL-BIO-AJ-003
Short DescriptionOur discovery of a novel proto-oncogene over-expressed in the early stages of many human cancers has tremendous potential for early detection and treatment.
AbstractNone
 
Tagsbiomarker, cancer, diagnostic, early stage, genetic marker, global regulator, lifesciences, oncology, prognostic, proto-oncogene, therapeutic intervention, tumorigenesis
 
Posted DateApr 14, 2010 10:41 AM

Description

Our discovery of a novel proto-oncogene over-expressed in the early stages of many human cancers has tremendous potential for early detection and treatment. Using our genetically engineered mouse prostate cancer models we have found a novel proto-oncogene that is up-regulated during cancer initiation in vivo (tumorigenesis). Targeted over-expression of this proto-oncogene in otherwise normal mice induces prostate cancer, a significant finding shared with only a few other proto-oncogenes (i.e. myc, Ras) which have proven to be valuable therapeutic targets for certain cancers. We have shown that the phosphorylation status of this proto-oncogene is associated with cancer development and that cancer induced by this proto-oncogene is associated with the Ras signal transduction pathway that is involved in over 30% of cancers.

 

Preliminary results using RNA interference technology (shRNA) to suppress expression of this proto-oncogene in human prostate cancer cell lines demonstrated inhibition of cellular proliferation and tumor cell growth in vitro indicating that it could prove to be a global regulator of cell cycle control. Screening of tissues from over 300 patients and 35 tumor types has indicated that this proto-oncogene is over-expressed at the early stages of many human cancers, supporting its use as a biomarker for detection of tumorigenesis.

 

On-going studies indicate this novel proto-oncogene is a prime target for therapeutic intervention in multiple cancers.

Potential Applications

  • A novel proto-oncogene over-expressed in the early stages of multiple human cancer types including lung, breast, liver, skin, tongue, mouth, endometrial, kidney, and prostate that may be useful as a diagnostic/prognostic marker
  • A global regulator of cell cycle control that is a prime target for early stage therapeutic intervention in multiple cancers
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